Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer
نویسندگان
چکیده
Single nucleotide polymorphisms (SNPs) in TERT may be associated with susceptibility to esophageal cancer. In this study, we analyzed the association between TERT SNPs and risk of esophageal cancer in 386 esophageal cancer patients and 495 healthy subjects from the Xi'an area of China. Of the four SNPs examined, rs10069690 and rs2242652 were correlated with esophageal cancer risk. Additionally, after adjusting for age and gender, the "Trs10069690Ars2242652", "Trs10069690Grs2242652" haplotypes were associated with an increased risk of esophageal cancer, while the and "Crs10069690Grs2242652" haplotype was associated with a decreased risk of esophageal cancer. These findings suggest that TERT polymorphisms may contribute to the development of esophageal cancer.
منابع مشابه
بررسی همزمان پلی مورفیسم های ژنهای,GSTM11GSTT و ارتباط آنها با مقاومت نسبت به داروهای شیمیدرمانی در بیماران مبتلابه سرطان مری
Background: Genetic polymorphisms in enzymes involved in carcinogen metabolism have been shown to influence susceptibility to cancer. The glutathione S-transferase (GST) genes are involved in the detoxification of a broad range of toxic substances, so polymorphic deletions of GSTM1 and GSTT1 genes may involve as a risk factor for esophagus carcinoma. The aim of this research was to investigate ...
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